High Resolution Detection of Copy Number Variation (CNV’s)

Microarray genomic hybridization can detect submicroscopic copy number variants. CNVs are small deletions or duplications that can be pathogenic for certain conditions. Most often, however, CNV’s are benign polymorphisms that may be associated with common diseases. Microarrays are able to analyze the entire genome for changes in copy number in a single assay. There are many different microarray platforms available with varying technical specifications and BCCGN can help steer you to the one that is most appropriate for your study. State-of-the-art facilities are available for detection of CNVs on Affymetrix GeneChips®, SMRT tiling path BAC arrays, BeadChips and Nimblegen and Agilent oligonucleotide arrays depending on the application involved, one particular CNV measurement platform may be more appropriate or cost effective than another. In some circumstances, looking for balanced structural variants (e.g. inversions) may be more appropriate and high throughput sequencing is available for this purpose.

Resources: Affymetrix Gene Chip® SNP Arrays
SMRT tiling path BAC Arrays
Illumina® 500GX BeadChip SNP Arrays
Agilent® Whole Genome Oligonucleotide Arrays
NimbleGen® Whole Genome Oligonucleotide Arrays
Location: Genome Sciences Centre
BC Cancer Research Center
Child and Family Research Institute
VGH Prostate Centre
BCCH Molecular Cytogenetics Lab
Key Services: High resolution detection of CNV’s


Find out more:
High Throughput Genotyping | High Throughput DNA Sequencing |
Chromotyping (High Throughput Epigenetic Analysis)